This is an internationally respected and authoritative work, providing in-depth coverage of all aspects of pleural disease. Building on the strengths of the well-received first edition, the book includes a thorough basic science section, aiding understanding of the physiological and pathophysiological mechanisms that underlie diseases of the pleura. This is followed by a series of chapters discussing clinical aspects of the common (and less common) pleural diseases. Chapters in the clinical section--with authors from 10 countries--are written in an accessible and uniform style, making extensive use of illustrative material and covering definition, incidence and epidemiology, etiology and pathogenesis, clinical presentation, investigations, treatments, possible complications and directions for future developmetn. Chapters present 'state-of-the-art' scientific knowledge, but are written with sufficient clarity as to be understood by clinicians with only a limited science background. All published managment guidelines are included, each chapter concludes with a summary of the 'key points,' highlighting practical messages regarding patient management for the reader, and a comprehensive reference list is provided. In a final chapter, the editors endeavour to rpedict how the area of pleural disease may develop in forthcoming decades.
The book is an indispensable reference for pulmonologists with an interest in pleural disease, and is a useful reference for other pulmonary physicians and trainees in respiratory medicine.
Pleural disease: historic perspective
PART ONE: Basic Science
Anatomy of the pleura
Mesothelial cells
Normal physiological fluid and cellular contents
Physiology: fluid and solute exchange in normal physiological states
Physiology: changes with pleural effusion and pneumothorax
Pleural inflammation and infection
Immunology
Pleural fibrosis
Pleural reaction to mineral dusts
Genetic alterations in mesothelioma pathogenesis
Proteomics in pleural disease
Pleural pharmacokinetics
Experimental models: pleural disease other than mesothelioma
Experimental models: mesothelioma
PART TWO: Clinical Science
Approach to patients with pleural diseases
Pleural fluid analysis
Pleural manometry
Radiology: diagnostic
Radiology: interventional
Radiology: pleural ultrasound
Pathology: histology
Pathology: cytology
EFFUSIONS
Effusions from cardiac diseases
Effusions from malignancy
Effusions from infections: parapneumonic effusions and empyema
Effusions from infections: tuberculosis
Effusions from infections: atypical infections
Effusions from lymphatic disruptions
Effusions from vascular causes
Effusions in immunocompromised hosts
Effusions from connective tissue diseases
Effusions caused by drugs
Effusions after surgery
Hepatic hydrothorax
Effusions caused by gastrointestinal disease
Effusions of obstetric or gynecological origin
Benign fibrous tumor of the pleura
Undiagnosed pleural effusions
ASBESTOS-RELATED DISEASES
Asbestos-related pleural diseases
Malignant mesothelioma
PNEUMOTHORAX
Spontaneous pneumothorax
Non-spontaneous pneumothorax
PEDIATRIC CONSIDERATIONS
Pediatric pleural diseases
INTERVENTION PROCEDURES
Drainage techniques
Pleurodesis
Medical thoracoscopy
Surgery for pleural diseases
Gene therapy in pleural diseases
CONCLUSION
Future directions