Effectively perform today?s most effective, state-of-the-art neurosurgical procedures with Youmans Neurological Surgery, 6th Edition, edited by H. Richard Winn, MD. Still the cornerstone of unquestioned guidance on surgery of the nervous system, the new edition updates you on the most exciting developments in this ever-changing field. In print and online, it provides all the cutting-edge details you need to know about functional and restorative neurosurgery/deep brain stimulation, stem cell biology, radiological and nuclear imaging, neuro-oncology, and much more. And with nearly 100 intraoperative videos online at www.expertconsult.com, as well as thousands of full-color illustrations, this comprehensive, multimedia, 4-volume set remains the clinical neurosurgery reference you need to manage and avoid complications, overcome challenges, and maximize patient outcomes.

"There is no doubt that Neurological Surgery is the grand dame of the major neurosurgical textbooks?and is recommended without hesitation."- JAMA, (review of 4th edition)

VOLUME 1 SECTION I Introduction to Neurological Surgery PART 1 History Chapter 1 Historical Overview of Neurosurgery James Tait Goodrich and Eugene S. Flamm PART 2 Basic Science Chapter 2 Surgical Anatomy of the Brain Hung Tzu Wen, Albert L. Rhoton Jr, and Antônio C. M. Mussi Chapter 3 Molecular Biology Primer for Neurosurgeons Kevin Y. Miyashiro and James Eberwine Chapter 4 Neuroembryology Harvey B. Sarnat, Laura Flores-Sarnat, and Joseph D. Pinter Chapter 5 Stem Cell Biology in the Central Nervous System Philip J. Horner and Samuel E. Nutt Chapter 6 Neurons and Neuroglia Bruce D. Trapp and Karl Herrup Chapter 7 Cellular Mechanisms of Brain Energy Metabolism Albert Gjedde and Pierre Magistretti Chapter 8 Blood-Brain Barrier Shahid M. Nimjee, Gerald A. Grant, H. Richard Winn, and Damir Janigro Chapter 9 Cerebral Edema Robert J. Weil and Edward H. Oldfield Chapter 10 Physiology of the Cerebrospinal Fluid and Intracranial Pressure ?Anthony Marmarou and Andrew Beaumont Chapter 11 Neurosurgical Epidemiology and Outcomes Assessment Hugh Garton, Frederick G. Barker II, and Stephen J. Haines parT 3 Approach To The Patient Chapter 12 Altered Consciousness Nicholas D. Schiff Chapter 13 Neuroophthalmology Timothy J. Martin and James J. Corbett Chapter 14 Neurotology P. Ashley Wackym and Christina L. Runge-Samuelson Chapter 15 Neurourology Brett D. Lebed and Eric S. Rovner Chapter 16 Neuropsychological Testing Jordan Grafman parT 4 Radiologic Fundamentals Chapter 17 Computed Tomography and Magnetic Resonance Imaging of the Brain Thomas Aquinas Kim, Aleksandrs Uldis Kalnins, and Robert W. Prost Chapter 18 Radiology of the Spine Ajit Krishnaney and Michael T. Modic Chapter 19 Physiologic Evaluation of the Brain with Magnetic Resonance Imaging Amish H. Doshi, Pascal Bou-Haidar, and Bradley Delman Chapter 20 Molecular Imaging of the Brain with Positron Emission Tomography William P. Melega and Antonio A. F. De Salles SECTION II General Neurosurgery parT 1 Perioperative Care Chapter 21 Neuroanesthesia: Preoperative Evaluation Deepak Sharma and Arthur M. Lam Chapter 22 Avoidance of Complications in Neurosurgery Nirit Weiss and Kalmon D. Post Chapter 23 Intracranial Pressure Monitoring Vincent Y. Wang and Geoffrey T. Manley Chapter 24 Principles of Neurocritical Care Eelco F. M. Wijdicks and Alexander Y. Zubkov parT 2 General Principles and Surgical Techniques Chapter 25 Surgical Planning: Overview Martin Weiss, Gabriel Zada, and Alexander A. Khalessi Chapter 26 Positioning for Cranial Surgery R. Webster Crowley, Aaron S. Dumont, M. Sean McKisic, and John A. Jane Sr Chapter 27 Patient Positioning for Spinal Surgery Peter D. Angevine, Paul R. Gigante, and Paul C. McCormick Chapter 28 Positioning in Peripheral Nerve Surgery Allen H. Maniker Chapter 29 Incisions and Closures Stirling Craig and John A. Persing Chapter 30 Advantages and Limitations of Cranial Endoscopy Jeroen R. Coppens and William T. Couldwell Chapter 31 Thorascopic Spine Surgery Rudolf Beisse Chapter 32 Cranioplasty Robert G. Whitmore, Shabbar F. Danish, and M. Sean Grady parT 3 Geriatric Neurosurgery Evaluation of Adult Hydrocephalus Chapter 33 Production and Flow of Cerebrospinal Fluid Conrad E. Johanson Chapter 34 Clinical Evaluation of Adult Hydrocephalus Nicole C. Keong, Marek Czosnyka, Zofia Czosnyka, and John D. Pickard Management of Adult Hydrocephalus Chapter 35 Shunting Marvin Bergsneider and Eric Stiner Chapter 36 Adult Hydrocephalus: The Role of Endoscopic Third Ventriculostomy Jay Riva-Cambrin and James Drake Subdural Hematomas Chapter 37 Pathophysiology of Subdural Hematomas Brent O?Neill, Jack Wilberger, and Adam Wilberger Chapter 38 Medical and Surgical Management of Chronic Subdural Hematomas Joachim K. Krauss, Lawrence F. Marshall, and Ralf Weigel parT 4 Infection Chapter 39 Basic Science of Central Nervous System Infections Jeffrey M. Tessier and W. Michael Scheld Chapter 40 Postoperative Infections of the Head and Brain Christopher J. Farrell, Mary L. Pisculli, and Frederick G. Barker II Chapter 41 Postoperative Infections of the Spine Michael A. Finn and Meic H. Schmidt Chapter 42 The Use and Misuse of Antibiotics in Neurosurgery Koijan Kainth, Matthew A. Hunt, and Stephen J. Haines Chapter 43 Brain Abscess Allan R. Tunkel and W. Michael Scheld Chapter 44 Meningitis and Encephalitis Ian E. McCutcheon Chapter 45 Acquired Immune Deficiency Syndrome M. Kelly Nicholas, Rimas V. Lukas, and Koen van Besien Chapter 46 Parasitic Infections Oscar H. Del Brutto, Juan J. Figueroa, and Hector H. Garcia Chapter 47 Surgical Risk of Transmittable Diseases Donald E. Fry SECTION III Epilepsy parT 1 Basic Science of Epilepsy Chapter 48 Epilepsy Surgery Overview Guy M. McKhann II and Matthew A. Howard III Chapter 49 Electrophysiologic Properties of the Mammalian Central Nervous System Guy M. McKhann II and Damir Janigro Chapter 50 Animal Models of Epilepsy Maria Elisa Calcagnotto and Scott C.Baraban Chapter 51 Malformations of Cortical Development Gregory G. Heuer and Peter B. Crino parT 2 Approach to the Patient Chapter 52 Diagnosis and Classification of Seizures and Epilepsy Frank Gilliam Chapter 53 Antiepileptic Medications: Principles of Clinical Use Blaise F. D. Bourgeois parT 3 Preoperative Evaluation For Epilepsy Chapter 54 Continuous Electroencephalography in Neurological-Neurosurgical Intensive Care: Applications and Value Hiba Arif, Jan Claassen, and Lawrence J. Hirsch Chapter 55 Neuroradiologic Evaluation for Epilepsy Surgery Suzan Dyve, Leif Sørensen, Adam N. Mamelak, William W. Sutherling, and Gregory D. Cascino Chapter 56 Evaluation of Patients for Epilepsy Surgery Costas Michaelides, Garth Rees Cosgrove, and Andrew J. Cole parT 4 Intraoperative Mapping and Monitoring for Cortical Resections Chapter 57 Motor, Sensory, and Language Mapping and Monitoring for Cortical Resections Ben Waldau and Michael M. Haglund Chapter 58 Auditory Language Mapping Zachary Wright and Guy M. McKhann II Chapter 59 Investigation of Human Cognition in Epilepsy Surgery Patients Hiroto Kawasaki and Chandan G. Reddy parT 5 Specific Operative Approaches Chapter 60 Intracranial Monitoring Kenneth P. Vives, Andy J. Redmond, and Dennis D. Spencer Chapter 61 Surgery for Extratemporal Lobe Epilepsy James W. Leiphart and Itzhak Fried Chapter 62 Standard Temporal Lobectomy William Bingaman and Imad Najm Chapter 63 Selective Amygdalohippocampectomy Kim J. Burchiel, Andrew C. Zacest, and David Spencer Chapter 64 Tailored Resections for Epilepsy David W. Roberts Chapter 65 Topectomy and Multiple Subpial Transection Patrick J. Connolly, Atsushi Umemura, Gordon H. Baltuch, and Richard W. Byrne Chapter 66 Hemispheric Disconnection Procedures Johannes Schramm Chapter 67 Vagus Nerve Stimulation for Intractable Epilepsy James E. Baumgartner and Gretchen K. Von Allmen Chapter 68 Radiosurgical Treatment of Epilepsy Isaac Yang, Edward F. Chang, Nicholas M. Barbaro, Jean Régis, Marc Lévêque, Fabrice Bartolomei, and Patrick Chauvel Chapter 69 Deep Brain Stimulation for Epilepsy Robert S. Fisher, Brian Litt, and William C. Stacey Chapter 70 Epilepsy Surgery: Outcome and Complications Anthony L. Petraglia, Christian B. Kaufman, and Webster H. Pilcher SECTION IV Functional Neurosurgery parT 1 Overview Chapter 71 Introduction Andres M. Lozano and Ron L. Alterman parT 2 Basic Science of Movement Disorders Chapter 72 Anatomy and Synaptic Connectivity of the Basal Ganglia Yoland Smith Chapter 73 Rationale for Surgical Interventions in Movement Disorders Thomas Wichmann and Mahlon R. DeLong Chapter 74 Neuropathology of Movement Disorders Kurt A. Jellinger parT 3 Neurology of Movement Disorders Chapter 75 Clinical Overview of Movement Disorders Ihtsham ul Haq, Kelly D. Foote, and Michael S. Okun Chapter 76 Patient Selection Criteria for Deep Brain Stimulation in Movement Disorders Ioannis U. Isaias and Michele Tagliati Chapter 77 Functional Imaging in Movement Disorders David J. Brooks and Nicola Pavese parT 4 Surgery for Movement Disorders Chapter 78 Surgical Management of Tremor Kazutaka Kobayashi, Jong Hyun Kim, William S. Anderson, and Frederick A. Lenz Chapter 79 Pallidal Interventions for Parkinson?s Disease Philip A. Starr Chapter 80 Subthalamic Deep Brain Stimulation for Parkinson?s Disease Alim Louis Benabid, John Mitrofanis, Stéphan Chabardés, Eric Seigneuret, Napoleon Torres, Brigitte Piallat, Abdelhamid Benazzouz, Valerie Fraix, Paul Krack, Pierre Pollak, Sylvie Grand, and Jean François LeBas Chapter 81 Subthalamotomy in Parkinson?s Disease: Indications and Outcome Jorge Guridi, Lázaro Alvarez, Raul Macias, and José A. Obeso Chapter 82 Deep Brain Stimulation for Dystonia Ron L. Alterman Chapter 83 Deep Brain Stimulation: Mechanisms of Action Matthew D. Johnson, Cameron C. McIntyre, and Jerrold L. Vitek Chapter 84 Emerging and Experimental Neurosurgical Treatments for Parkinson?s Disease Scellig Stone, Karim Mukhida, and Andres M. Lozano Chapter 85 Selective Peripheral Denervation for Cervical Dystonia Joachim K. Krauss parT 5 Surgery for Psychiatric Disorders Chapter 86 A History of Psychosurgery Patrick M. Schweder and Garth Rees Cosgrove Chapter 87 Surgery for Tourette?s Syndrome Robert J. Maciunas and Brian N. Maddux Chapter 88 Surgery for Obsessive-Compulsive Disorder Ali R. Rezai, Andre Machado, Donald A. Malone Jr, and Benjamin Greenberg Chapter 89 Surgical Treatment of Major Depression Clement Hamani, Brian Snyder, Adrian W. Laxton, Paul E. Holtzheimer, Helen S. Mayberg, and Andres M. Lozano parT 6 Surgical Interventions for Spasticity Chapter 90 Ablative Surgery for Spasticity Marc Sindou and Patrick Mertens Chapter 91 Management of Spasticity by Central Nervous System Infusion Techniques Richard D. Penn and Daniel M. Corcos parT 7 Miscellaneous Chapter 92 Treatment of Intractable Vertigo Zackary E. Boomsaad, Steven A. Telian, and Parag G. Patil Chapter 93 Treatment Applications of Cortical Stimulation Jay L. Shils and Jeffrey E. Arle Chapter 94 Neuroprosthetics Jacob A. Donoghue, Jacob H. Bagley, Gerhard M. Friehs, and Vasilios A. Zerris VOLUME 2 SECTION V Oncology parT 1 Overview Chapter 95 Brain Tumors: General Considerations Henry Brem, E. Antonio Chiocca, and Raymond Sawaya parT 2 Basic Science of Neurooncology Chapter 96 Brain Tumors: An Overview of Current Histopathologic Classifications Gregory N. Fuller and Teresa Ribalta Chapter 97 Brain Tumor Immunology and Immunotherapy Roberta P. Glick, Terry Lichtor, and Amy B. Heimberger Chapter 98 Brain Tumor Stem Cells Hasan A. Zaidi, Francesco Di Meco, and Alfredo Quiñones-Hinojosa Chapter 99 Proliferation Markers in the Evaluation of Gliomas Tarik Tihan Chapter 100 Molecular Genetics and the Development of Targets for Glioma Therapy Nduka M. Amankulor and Eric C. Holland Chapter 101 Growth Factors in Glial Tumors Abhijit Guha and David Omahen Chapter 102 The Genetic Origins of Brain Tumors Gregory J. Riggins Chapter 103 Invasion in Malignant Glioma Ian Lee and Mark L. Rosenblum