This volume is based on presentations by world-renowned investigators who gathered at the 76th Cold Spring Harbor Symposium on Quantitative Biology. It reviews the latest advances in our understanding of metabolism and disease, including research on fat, exercise and rhythms; insulin resistance and sensitivity; lifespan, aging and cancer; regulation and dysregulation of metabolism; signaling and gene regulation; environment and sensing; metabolic reprogramming; clocks and intermediary metabolism; metabolism and cancer; and autophagy, timing and small RNAs.

Symposium Participants Foreword Introduction Bioenergetic Origins of Complexity and Disease D.C. Wallace Nuclear Receptors and AMPK: Resetting Metabolism W. Fan, M. Downes, A. Atkins, R. Yu, and R.M. Evans Rethinking the Regulation of Cellular Metabolism C.B. Thompson Clocks and Rhythms The Time of Metabolism: NAD+, SIRT1, and the Circadian Clock M.M. Bellet, R. Orozco-Solis, S. Sahar, K. Eckel-Mahan, and P. Sassone-Corsi The Mammalian Circadian Timing System: Synchronization of Peripheral Clocks C. Saini, D.M. Suter, A. Liani, P. Gos, and U. Schibler Circadian Epigenomic Remodeling and Hepatic Lipogenesis: Lessons from HDAC3 Z. Sun, D. Feng, L.J. Everett, A. Bugge, and M.A. Lazar Estrogen-Related Receptor ?, the Molecular Clock, and Transcriptional Control of Metabolic Outputs V. Giguère, C.R. Dufour, L.J. Eichner, G. Deblois, and N. Cermakian Circadian Clocks in Fuel Harvesting and Energy Homeostasis K.M Ramsey and J. Bass Life Span and Aging Gamete Formation Resets the Aging Clock in Yeast E. Ünal and A. Amon Sirtuins, Aging, and Metabolism L. Guarente The Heat Shock Response: Systems Biology of Proteotoxic Stress in Aging and Disease R.I. Morimoto Skeletal Muscle Stem Cells: Effects of Aging and Metabolism on Muscle Regenerative Function Y.C. Jang, M. Sinha, M. Cerletti, C. Dall?Osso, and A.J. Wagers The C. elegans DAF-2 Insulin-Like Receptor is Abundantly Expressed in the Nervous System and Regulated by Nutritional Status K.D. Kimura, D.L. Riddle, and G. Ruvkun Regulation and Dysregulation of Metabolism Surviving Starvation: Essential Role of the Ghrelin-Growth Hormone Axis J.L. Goldstein, T.-j. Zhao, R.L. Li, D.P. Sherbet, G. Liang, and M.S. Brown Transcriptional and Posttranscriptional Control of Cholesterol Homeostasis by Liver X Receptors P. Tontonoz Roles of FGF19 in Liver Metabolism S. Kir, S.A. Kliewer, and D.J. Mangelsdorf A New Approach to an Old Problem: Synthetic Biology Tools for Human Disease and Metabolism D.R. Burrill, P.M. Boyle, and P.A. Silver Signaling and Gene Regulation Adenosine Monophosphate?Activated Protein Kinase: A Central Regulator of Metabolism with Roles in Diabetes, Cancer, and Viral Infection D.G. Hardie Regulated Histone Methyltransferase and Demethylase Complexes in the Control of Genes by Nuclear Receptors A. Yokoyama, R. Fujiki, F. Ohtake, and S. Kato Transcriptional Control of Cardiac Fuel Metabolism and Mitochondrial Function T.C. Leone and D.P. Kelly Metabolic Specialization of Mouse Embryonic Stem Cells J. Wang, P. Alexander, S.L. McKnight On Acetyl-CoA as a Gauge of Cellular Metabolic State L. Cai and B.P. Tu Metabolic Reprogramming Nutrient-Dependent Acetylation Controls Basic Regulatory Metabolic Switches and Cellular Reprogramming J.E. Dominy, Z. Gerhart-Hines, and P. Puigserver Control of Glycolysis through Regulation of PFK1: Old Friends and Recent Additions I. Mor, E.C. Cheung, and K.H. Vousden ENTPD5, an Endoplasmic Reticulum (ER) UDPase, Alleviates ER Stress Induced by Protein Overloading in AKT-Activated Cancer Cells Z. Shen, S. Huang, M. Fang, and X. Wang MicroRNAs in Metabolism and Metabolic Diseases V. Rottiers, S.H. Najafi-Shoushtari, F. Kristo, S. Gurumurthy, L. Zhong, Y. Li, D.E Cohen, R.E. Gerszten, N. Bardeesy, R. Mostoslavsky, and A.M. Näär Metabolomics in Drug Target Discovery J.D. Rabinowitz, J.G. Purdy, L. Vastag, T. Shenk, and E. Koyuncu Fat, Intermediary Metabolism, and Exercise Transcriptional Networks Controlling Adipocyte Differentiation R. Siersbæk and S. Mandrup Adiponectin, Adiponectin Receptors, and Epigenetic Regulation of Adipogenesis T. Kadowaki, T. Yamauchi, H. Waki, M. Iwabu, M. Okada-Iwabu, and M. Nakamura SIRT3 Regulates Mitochondrial Protein Acetylation and Intermediary Metabolism M.D. Hirschey, T. Shimazu, J.-Y. Huang, B. Schwer, and E. Verdin Regulation of Male Fertility by Bone G. Karsenty Regulation of Glycolysis and Gluconeogenesis by Acetylation of PKM and PEPCK Y. Xiong, Q-Y. Lei, S. Zhao, and K-L. Guan NAD+ as a Signaling Molecule Modulating Metabolism C. Cantó and J. Auwerx Metabolism and Cancer Cancer Cell Metabolism R.A. Cairns, I. Harris, S. McCracken, and T.W. Mak Extracellular Matrix Regulation of Metabolism and Implications for Tumorigenesis A.R. Grassian, J.L. Coloff, and J.S. Brugge Metabolic Pathway Alterations that Support Cell Proliferation M.G. Vander Heiden, S.Y. Lunt, T.L. Dayton, B.P. Fiske, W.J. Israelsen, K.R. Mattaini, N.I. Vokes, G. Stephanopoulos, L.C. Cantley, C.M. Metallo, and J.W. Locasale Cancer and Altered Metabolism: Potential Importance of Hypoxia-Inducible Factor and 2-Oxoglutarate-Dependent Dioxygenases W.G. Kaelin, Jr. Regulation of Metabolism by Hypoxia-Inducible Factor 1 G.L. Semenza mRNA Translation and Energy Metabolism in Cancer: The Role of the MAPK and mTORC1 Pathways I. Topisirovic and N. Sonenberg Therapeutic Targeting of Myc-Reprogrammed Cancer Cell Metabolism C.V. Dang Apoptosis and Autophagy Integration of Apoptosis and Metabolism C.H. Yi, H. Vakifahmetoglu-Norberg, and J. Yuan Autophagy, Stress, and Cancer Metabolism: What Doesn?t Kill You Makes You Stronger R. Mathew and E. White Autophagy in Protein and Organelle Turnover N. Mizushima Summary: Back to the Future: Molecular Biology Meets Metabolism S. McKnight Author Index Subject Index