From Ernest L. Mazzaferri, MD MACP: ". . . experts in their respective areas, provide succinct editorial comments with references for each article, which the practicing physician will find useful in day-to-day practice." There's no faster or easier way to stay informed! The Year Book of Endocrinology brings you abstracts of the articles that reported the year's breakthrough developments in endocrinology carefully selected from more than 500 journals worldwide. Expert commentaries evaluate the clinical importance of each article and discuss its application to your practice.

Journals Represented xiii Introduction xv Editor's Choice xvii Diabetes 1 Section A 1 Introduction 1 Prevention and Reversal of Diabetes 2 Glycemic Control 11 Diabetic Complications 16 Diabetes and Aging 24 Compliance With Treatment 30 Section B 31 Introduction 31 Epidemiology 32 Pathogenesis 43 Treatments 51 Complications 77 Future 81 Lipoproteins and Atherosclerosis 87 Introduction 87 Epidemiology and Diagnosis 90 Prevention of Atherosclerosis 94 Nutrition and Nutritional Supplements 97 Metabolic Syndrome 104 Clinical Trials of Drug Therapy 106 Pharmacologic Therapy 116 Compliance With Pharmacologic Therapy 123 Pleiotropic Effects of Statin Therapy 127 Stroke and Peripheral Artery Disease 130 Obesity 133 Introduction 133 Epidemiology and Complications of Obesity 134 Diet and Obesity 140 Physical Activity and Obesity 146 Pharmacologic Treatment of Obesity 149 Surgical Treatment of Obesity 157 New Developments in Obesity 163 Thyroid 167 Introduction 167 Subclinical Thyroid Disease 168 Thyrotoxicosis 185 Hypothyroidism 205 Thyroid Disease in Pregnancy 215 Thyroid Nodules 226 Thyroid Cancer 247 Euthyroid Goiter 302 Calcium and Bone Metabolism 313 Introduction 313 Mineral and Vitamin D Metabolism 316 Epidemiology and Pathophysiology of Osteoporosis 325 Current Issues in Osteoporosis Therapy 330 Novel Osteoporosis Therapies 346 Osteoporosis in Other Settings 350 Metabolic Bone Disease 353 Adrenal Cortex 357 Introduction 357 Adrenal Hormone Secretion and Pathology 358 Glucocorticoid Receptors/Glucocorticoid Sensitivity 361 Adrenal Function 364 Cushing's Disease: Diagnosis and Treatment 369 Pheochromocytomas: Diagnosis and Treatment 371 Congenital Adrenal Hyperplasia 374 Primary Aldosteronism 376 Autoimmunity and Addison's Disease 378 Reproductive Endocrinology 381 Introduction 381 Female Reproductive Function and Menopause 381 Introduction 381 Polycystic Ovary Syndrome 385 Introduction 385 Osteoporosis in Women 393 Introduction 393 Female Replacement Therapy 395 Introduction 395 Estrogen and Coronary Artery Disease 398 Introduction 398 Male Hormone Replacement 402 Introduction 402 Hypogonadism and Aging 406 Introduction 406 Bone Health in Men 410 Introduction 410 Metabolic Syndrome and Hypogonadism 413 Introduction 413 Neuroendocrinology 419 Introduction 419 Growth Hormone 20 Prolactin 436 ACTH 439 Pituitary-General 442 Posterior Pituitary 450 Pediatric Endocrinology 453 Introduction 453 Pituitary 455 Bone/Calcium 460 Growth/Growth Hormone 464 Miscellaneous 466 Subject Index 475 Author Index 491