After thirty years, "PPID" is still the reference of choice for comprehensive, global guidance on diagnosing and treating the most challenging infectious diseases. Drs. Mandell, Bennett, and Dolin have substantially revised and meticulously updated, this new edition to save you time and to ensure you have the latest clinical and scientific knowledge at your fingertips. With new chapters, expanded and updated coverage, increased worldwide perspectives, and many new contributors, "Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases, 7th Edition" helps you identify and treat whatever infectious disease you see. And, as "An Expert Consult" title with enhanced online features, this updated 7th edition comes with convenient access to the full text online, and regular updates on the new developments in the field and advances in therapy.

Part I Basic Principles in the Diagnosis and Management of Infectious Diseases Section A. Microbial Pathogenesis 1 A Molecular Perspective of Microbial Pathogenicity 2 Microbial Adherence 3 Toxins Section B. Host Defense Mechanisms 4 Innate (General or Nonspecific) Host Defense Mechanisms 5 Human Genetics and Infection 6 Antibodies 7 Complement 8 Granulocytic Phagocytes 9 Cell-Mediated Defense Against Infection 10 Nutrition, Immunity, and Infection 11 Probiotics 12 Evaluation of the Patient with Suspected Immunodeficiency Section C. Epidemiology of Infectious Diseases 13 Epidemiologic Principles 14 Outbreak Investigation 15 Emerging and Reemerging Infectious Disease Threats 16 Hospital Preparedness for Emerging and Highly Contagious Infectious Diseases Section D. Clinical Microbiology 17 The Clinician and the Microbiology Laboratory Section E. Anti-Infective Therapy 18 Principles of Anti-infective Therapy 19 Molecular Mechanisms of Antibiotic Resistance in Bacteria 20 Pharmacokinetics and Pharmacodynamics of Anti-infective Agents 21 Penicillins 22 Cephalosporins 23 Other -Lactam Antibiotics 24 -Lactam Allergy 25 Fusidic Acid 26 Aminoglycosides 27 Tetracyclines and Chloramphenicol 28 Rifamycins 29 Metronidazole 30 Macrolides, Clindamycin, and Ketolides 31 Glycopeptides, Streptogramins, and Lipopeptides 32 Polymyxins (Polymyxin B and Colistin) 33 Oxazolidinones 34 Sulfonamides and Trimethoprim 35 Quinolones 36 Unique Antibacterial Agents 37 Urinary Tract Agents: Nitrofurantoin and Methenamine 38 Topical Antibacterials 39 Antimycobacterial Agents 40 Antifungal Agents 41 Antiviral Drugs (Other Than Antiretrovirals) 42 Immunomodulators 43 Hyperbaric Oxygen 44 Agents Active against Parasites and Pneumocystis 45 Complementary and Alternative Medicines for Infectious Diseases 46 Antimicrobial Management: Cost and Resistance 47 Interpretation of Clinical Trials of Antimicrobial Agents 48 Outpatient Parenteral Antimicrobial Therapy 49 Tables of Antimicrobial Agent Pharmacology Part II Major Clinical Syndromes Section A. Fever 50 Temperature Regulation and the Pathogenesis of Fever 51 Fever of Unknown Origin 52 The Acutely Ill Patient with Fever and Rash Section B. Upper Respiratory Tract Infections 53 The Common Cold 54 Pharyngitis 55 Actue Laryngitis 56 Acute Laryngotracheobronchitis (Croup) 57 Otitis Externa, Otitis Media, and Mastoiditis 58 Sinusitis 59 Epiglottitis 60 Infections of the Oral Cavity, Neck, and Head Section C. Pleuropulmonary and Bronchial Infections 61 Acute Bronchitis 62 COPD, Chronic Bronchitis, and Acute Exacerbations 63 Bronchiolitis 64 Acute Pneumonia 65 Empyema and Pleural Effusion 66 Lung Abscess 67 Chronic Pneumonia 68 Cystic Fibrosis Section D. Urinary Tract Infections 69 Urinary Tract Infections Section E. Sepsis 70 Sepsis, Severe Sepsis, and Septic Shock Section F. Intra-abdominal Infection 71 Peritonitis and Intraperitoneal Abscesses 72 Infections of the Liver and Biliary System 73 Pancreatic Infections 74 Splenic Abscess 75 Appendicitis 76 Diverticulitis and Typhlitis Section G. Cardiovascular Infections 77 Endocarditis and Intravascular Infections 78 Prosthetic Valve Endocarditis 79 Infections of Non-Valvular Cardiovascular Devices 80 Prophylaxis of Infective Endocarditis 81 Myocarditis and Pericarditis 82 Mediastinitis Section H. Central Nervous System Infections 83 Approach to the Patient with Central Nervous System Infection 84 Acute Meningitis 85 Infections of CSF Shunts 86 Chronic Meningitis 87 Encephalitis, Myelitis, and Neuritis 88 Brain Abscess 89 Subdural Empyema, Epidural Abscess, and Intracranial Suppurative Thrombophlebitis Section I. Skin and Soft Tissue Infections 90 Cellulitis, Necrotizing Fasciitis and Subcutaneous Tissue Infections 91 Myositis 92 Lymphadenitis and Lymphangitis Section J. Gastrointestinal Infections and Food Poisoning 93 Principles and Syndromes of Enteric Infection 94 Esophagitis 95 Nausea, Vomiting, and Noninflammatory Diarrhea 96 Antibiotic