Immunobiology, Sixth Edition guides the reader through the immune system in all its aspects - from the first engagement of innate immunity to the generation of the adaptive immune response and its clinical consequences. The Sixth Edition has been thoroughly revised and updated, and now includes end-of-chapter questions. Immunobiology sets the standard for currency and authority with its clear writing style and organization, full-color art program, scientific accuracy, frequent updates, and consistent viewpoint - that of the host's interaction with an environment containing many species of potentially harmful microorganisms.

Part I An Introduction to Immunobiology and Innate Immunity Chapter 1 Basic Concepts in Immunology 1 Chapter 2 Innate Immunity 37 Part II The Recognition of Antigen Chapter 3 Antigen Recognition by B-cell and T-cell Receptors 103 Chapter 4 The Generation of Lymphocyte Antigen Receptors 135 Chapter 5 Antigen Presentation to T Lymphocytes 169 Part III The Development of Mature Lymphocyte Receptor Repertoires Chapter 6 Signaling Through Immune System Receptors 203 Chapter 7 The Development and Survival of Lymphocytes 241 Part IV The Adaptive Immune Response Chapter 8 T Cell-Mediated Immunity 319 Chapter 9 The Humoral Immune Response 367 Chapter 10 Adaptive Immunity to Infection 409 Part V The Immune System in Health and Disease Chapter 11 Failures of Host Defense Mechanisms 461 Chapter 12 Allergy and Hypersensitivity 517 Chapter 13 Autoimmunity and Transplantation 557 Chapter 14 Manipulation of the Immune Response 613 Part VI The Origins of Immune Responses Chapter 15 Evolution of the Innate Immune System 665 Appendix I Immunologists' Toolbox 683 Appendix II CD Antigens 731 Appendix III Cytokines and their Receptors 747 Appendix IV Chemokines and their Receptors 750 Appendix V Immunological Constants 751 Biographies 752 Glossary 753 Index 778