First described as ?the shaking palsy? in 1817 by James Parkinson, Parkinson?s disease is a disabling neurodegenerative disorder that is common among the elderly. It involves the gradual depletion of brain cells that control balance and movement, causing trembling, muscle rigidity, and difficulty walking. Characteristic brain changes ? such as the formation of Lewy bodies and the degeneration of dopamine-producing neurons ? have been identified, but diagnostic tests and therapeutic options remain limited. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine includes contributions covering all aspects of Parkinson?s disease, from its neuropathological and clinical bases to the diagnostic challenges and therapeutic interventions. Contributors discuss the mutations in genes encoding proteins such as ?-synuclein, parkin, and LRRK2 that cause Parkinson?s disease; the roles of mitochondria, autophagy, protein quality control, and programmed cell death in disease progression; and the chemistry and anatomy of the basal ganglia that are affected. The use of functional neuroimaging and experimental models to probe the neurobiology of Parkinson?s disease are also described. Blending both the clinical and basic science of Parkinson?s disease, this volume is a vital reference for neurobiologists, cell biologists, and pathologists pursuing the biological basis of Parkinson?s disease, as well as scientists and clinicians interested in its diagnosis and treatment.

Preface The History of Parkinson?s Disease: Early Clinical Descriptions and Neurological Therapies Christopher G. Goetz Clinical Approach to Parkinson?s Disease: Features, Diagnosis, and Principles of Management João Massano and Kailash P. Bhatia Parkinson?s Disease and Parkinsonism: Neuropathology Dennis W. Dickson Genetics of Parkinson?s Disease Christine Klein and Ana Westenberger ?-Synuclein in Parkinson?s Disease Leonidas Stefanis Leucine-Rich Repeat Kinase 2 for Beginners: Six Key Questions Lauren R. Kett and William T. Dauer Parkinsonism Due to Mutations in PINK1, Parkin, and DJ-1 and Oxidative Stress and Mitochondrial Pathways Mark R. Cookson Genomics and Bioinformatics of Parkinson?s Disease Sonja W. Scholz, Tim Mhyre, Habtom Ressom, Salim Shah, and Howard J. Federoff Parkinson?s Disease: Gene Therapies Philippe G. Coune, Bernard L. Schneider, and Patrick Aebischer Functional Neuroanatomy of the Basal Ganglia José L. Lanciego, Natasha Luquin, and José A. Obeso Functional Neuroimaging in Parkinson?s Disease Martin Niethammer, Andrew Feigin, and David Eidelberg Motor Control Abnormalities in Parkinson?s Disease Pietro Mazzoni, Britne Shabbott, and Juan Camilo Cortés Physiological Phenotype and Vulnerability in Parkinson?s Disease D. James Surmeier, Jaime N. Guzman, Javier Sanchez, and Paul T. Schumacker Modeling Parkinson?s Disease in Primates: The MPTP Model Gregory Porras, Qin Li, and Erwan Bezard A Guide to Neurotoxic Animal Models of Parkinson?s Disease Kim Tieu Animal Models of Parkinson?s Disease: Vertebrate Genetics Yunjong Lee, Valina L. Dawson, and Ted M. Dawson Drosophila as a Model to Study Mitochondrial Dysfunction in Parkinson?s Disease Ming Guo Mitochondrial Biology and Parkinson?s Disease Celine Perier and Miquel Vila The Role of Autophagy in Parkinson?s Disease Melinda A. Lynch-Day, Kai Mao, Ke Wang, Mantong Zhao, and Daniel J. Klionsky Disruption of Protein Quality Control in Parkinson?s Disease Casey Cook, Caroline Stetler, and Leonard Petrucelli Programmed Cell Death in Parkinson?s Disease Katerina Venderova and David S. Park Innate Inflammation in Parkinson?s Disease V. Hugh Perry Inflammation and Adaptive Immunity in Parkinson?s Disease R. Lee Mosely, Jessica A. Hutter-Saunders, David K. Stone, and Howard E. Gendelman Index