From the Preface: ?About every ten years a new book appears on any given medical specialty subject. Naturally, this is not because the entire body of knowledge on that specialty is overhauled every ten years but because the progress made over a decade usually warrants expressing new perspectives on quite a few diseases. Orbital oncology certainly qualifies as a subspecialty that merits an update every decade. At least two or three excellent textbooks on orbital tumors have been written since the mid-1980s. This book reports advances in knowledge about orbital diseases and their treatment and offers an up-to-date, single-volume reference for orbital tumors with particular emphasis on new improvements in diagnostic and therapeutic measures. Part I comprises advances in oncogenesis and its relationship to orbital tumors. Changes in the biological behavior of diseases in the general patient population are much slower than technological advances; nevertheless, those alterations take place as well. One of the major medical issues of our time, for example, is the changes in the immunological status of individuals. This issue influences the entire field of medicine, particularly oncology, including the treatment of orbital tumors. Chapters 2 to 5 summarize these influences. Medical genetics gained momentum during the past two decades and now affects the clinical practice of almost every discipline of medicine, including ophthalmology and orbitology. Chapters on principles of molecular genetics and immunosurveillance mechanisms of neoplasia and on the occurrence of multiplt, malignant neoplasms in retinoblastoma have been included to apply molecular concepts to clinical practice related to orbital tumors. Advances in one discipline often directly benefit practice in another field. In orbitology, no development has been more influential than the revolution in imaging techniques, including ultrasonography, computerized tomography, and magnetic resonance methods. Four chapters in Part II are devoted to the role of imaging in diganosis of orbital tumors. Other diagnostic advances entailing immunohistochemistry, flow cytometry, gene microarray, and the polymerase chain reaction are summarized in a separate chapter on orbital biopsy.?

Foreword Preface Acknowledgments Contributors Part I Current Concepts of Oncogenesis 1. Molecular Models of Cancer Development Domenico Mastrangelo 2 . Immune Surveillance Mechanisms in Cancer Domenico Mastrangelo 3 . The Changing Behavior of Orbital and Periorbital Tumors Alan A. McNab 4. Mechanisms of Tumor Metastasis in the Orbit J. Oscar Croxatto 5 . Multiple Malignancies in Retinoblastoma Zeynel A. Karcioglu Part II Diagnosis of Orbital Tumors 6 . Clinical Evaluation of the Orbit Zeynel A. Karcioglu 7 . Neuro-ophthalmologic Evaluation of the Orbit Andrew G. Lee 8 . Ultrasonography in Orbital Differential Diagnosis Amin M. Nasr and Grace A. Chacra 9 . The Basics of Orbital Imaging Paul Rosel 10 . Imaging in Orbital Differential Diagnosis Patrick De Potter 11 . New Concepts in Orbital Imaging Michael D. Abramoff 12 . Orbital Biopsy Zeynel A. Karcioglu and Luis Remus III Part III Primary Tumors of the Orbit 13 . Orbital Lymphoma Bita Esmaeli and Misha Faustina 14 . Vascular Tumors Kaan Gündüz and Zeynel A. Karcioglu 15 . Fibrohistiocytic Tumors Zeynel A. Karcioglu 16 . Fibro-osseous and Cartilaginous Tumors and Tumor-like Conditions Zeynel A. Karcioglu 17 . Peripheral Nerve Tumors Kaan Gündüz 18 . Lacrimal Gland Tumors Yoon-Duck Kim 19 . Tumors of the Lacrimal Drainage System Jeffrey J. Hurwitz Part IV Secondary Tumors of the Adult Orbit 20 . Periocular and Eyelid Tumors Georgina Kourt and Peter Martin 21 . Conjunctival Tumors Zeynel A. Karcioglu 22 . Ocular Tumors Zeynel A. Karcioglu and Doris Hadjistilianou 23 . Tumors of the Cranial and Nasal Cavities and Paranasal Sinuses Zeynel A. Karcioglu 24 . Metastatic Tumors J. Oscar Croxatto and Zeynel A. Karcioglu Part V Pediatric Orbital Tumors and Pseudotumors 25 . Benign Pediatric Tumors Zeynel A. Karcioglu and Johan Zwann 26 . Malignant Pediatric Tumors Doris Hadjistilianou and Zeynel A. Karcioglu . Part VI Tumor-like Conditions in the Orbit 27 . Orbital Inflammation and Infection versus Neoplasia Antonio Augusto V. Cruz 28 . Graves Disease Daniel Weil and Guillermo A. Fridrich 29 . Mass-Forming Inflammatory Lesions of the Orbit Zeynel A. Karcioglu Part VII Management of Orbital Tumors 30 . Staging of Orbital Tumors Zeynel A. Karcioglu and Barrett G. Haik 31 . Surgical Treatment Zeynel A. Karcioglu 32 . Computer Image Guidance and Skull-base Strategies Christopher R. Mascott and Zeynel A. Karcioglu 33 . Radiation Treatment Paul Finger 34 . Chemotherapy for Childhood Tumors Marta K. Rozans 35 . Chemotherapy for Adult Tumors Matthew W. Wilson and Carlos Galindo-Rodriquez Index