This work effectively responds to the pressing need for a clinically-oriented textbook that focuses on all aspects of intensity modulated radiation therapy (IMRT). Intensity Modulated Radiation Therapy: A Clinical Perspective is divided into three sections: Fundamentals, Clinical Implementation, and Clinical Sites. The book aims to provide a practical approach oriented text for radiation oncologists and physicists interested in commencing or expanding an IMRT program. It discusses the fundamentals of IMRT including physics and biology and provides a site-by-site review (i.e. breast, prostate, etc) of IMRT treatment techniques and outcomes with practical clinical examples. The content reviews published IMRT outcome studies and suggests possible future directions for IMRT research.

1 IMRT process 1 2 Physics of IMRT 20 3 Radiobiology of IMRT 53 4 Medicine of IMRT 75 5 CT simulation 83 6 Immobilization and localization 91 7 Imaging and fusion technologies 97 8 PET-CT in IMRT planning 115 9 Respiratory motion management 131 10 Treatment planning 149 11 Plan evaluation 166 12 Delivery systems 178 13 Commissioning and dosimetric quality assurance 186 14 Quality assurance processes and future directions 198 15 IMRT in the community setting 204 16 Billing and reimbursement 214 17 Central nervous system tumors : overview 231 17.1 Meningioma : case study 242 17.2 Base of skull tumor : case study 247 17.3 Glioblastoma multiforme : case study 253 17.4 Intensity-modulated radiosurgery : emerging technology 257 18 Head and neck cancer : overview 264 18.1 Nasopharyngeal cancer : case study 276 18.2 Ethmoid sinus cancer : case study 284 18.3 Maxillary sinus cancer : case study 289 18.4 Base of tongue cancer : case study 293 18.5 Pyriform sinus cancer : case study 301 18.6 Functional imaging in head and neck cancer : emerging technology 307 18.7 Simultaneous integrated boost : emerging technology 319 18.8 Modulated electron radiation therapy : emerging technology 327 18.9 Impact of prolonged treatment times : emerging technology 337 19 Lung cancer : overview 344 19.1 Target definition in non-small cell lung cancer : case study 358 19.2 Synchronous bilateral non-small cell lung cancer : case study 366 19.3 Helical tomotherapy for lung cancer : emerging technology 373 19.4 Intrafractional organ motion and planning : emerging technology 376 20 Breast cancer : overview 386 20.1 Intact breast cancer : case study 393 20.2 Accelerated concomitant boost : emerging technology 398 20.3 Real-time-3D-video-guided IMRT : emerging technology 407 21 Gastrointestinal tumors : overview 414 21.1 Pancreatic cancer : case study 423 21.2 Rectal cancer : case study 427 21.3 Anal cancer : case study 432 22A Intact prostate cancer : overview 436 22B Postoperative prostate cancer : overview 449 22.1 Intact prostate cancer : case study 459 22.2 Hypofractionated IMRT : case study 464 22.3 Targeted lymph node irradiation : case study 467 22.4 ProstaScint-guided IMRT : case study 475 22.5 Intra-prostatic boost : emerging technology 481 22.6 Repair of unacceptable implants : emerging technology 486 23 Gynecologic cancer : overview 492 23.1 Cervical cancer : case study 506 23.2 Endometrial cancer : case study 513 23.3 Cervical cancer not suitable for brachytherapy : case study 518 23.4 Bone marrow-sparing IMRT : emerging technology 523 23.5 Applicator-guided IMRT : emerging technology 531 24 Lymphoma : overview 535 24.1 Hodgkin's disease : case study 547 24.2 Helical tomotherapy - a new mantle : emerging technology 553 25 Sarcoma : overview 556 25.1 Paraspinal soft tissue sarcoma : case study 562 25.2 Retroperitoneal sarcoma : case study 568 26 Pediatric tumors : overview 573 26.1 Retinoblastoma : case study 579 26.2 Neuroblastoma : case study 584 26.3 Rhabdomyosarcoma : case study 588 27 Metastatic and recurrent tumors : overview 593 27.1 Recurrent spinal metastasis : case study 599 27.2 Recurrent nasopharyngeal cancer : case study 604 27.3 Intensity-modulated radiosurgery for spinal metastasis : emerging technology 609 28 Intensity-modulated proton therapy 615 29 Biologic modifiers and IMRT 622 30 Pros and cons of IMRT : what's been swept under the rug? 628