Since the last AFIP Fascicle on Tumors of the Skin, three decades have witnessed revolutionary advances in dermatopathology. The new fascicle concerning non-melanocytic tumors of the skin has sought to capture the spirit of these advances and display them in a form that is user friendly. Major subject categories include tumors of: epidermal keratinocytes; cutaneous eccrine, apocrine, and pilosebaceous adnexae; hematopoietic cells; fibrohistiocytic, neural, vascular, and smooth muscle lineage; and metastatic neoplasms to skin. Up-to-date technologies relevant to practical diagnostic issues are described and illustrated, e.g., in situ hybridiza-tion for detection of specific HPV types and Southern blot analysis for determi-nation of gene rearrangements in cutaneous Iymphoma. Ample use of differential diagnostic tables and charts facilitate rapid and efficient extraction of essential information and criteria, e.g., keratoacanthoma vs. cup-shaped squamous cell carcinoma, differential diagnosis of verrucous epidermal hyperplasia, differential diagnosis of spindle cell malignancies of skin, and benign Iymphoid hyperplasia vs. Iymphoma cutis. The numerous photomicrographs are generally grouped in clusters that illustrate progressive magnifications or important histologic, side-by-side comparisons. Attempts have been made to simplify nomenclature, in spite of the extraordinary proliferation of new entities that has typified the last few decades in dermatopathology. Areas that readers may find particularly useful include: extensive discussion of adnexal carcinoma; comprehensive and technologically up-to-date evaluation of Iympho-prolifera-tive neoplasia; detailed description and illustration of Kaposi sarcoma, includ-ing evolutionary stages; new diagnostic details for neuroendocrine carcinoma; and cutaneous and subcutaneous neo-plasia in children. The quality of both clinical and microscopic illustrations is outstanding in this first fascicle of the Third Series of the AFIP Tumor Atlas. Dermatologists as well as pathologists will find it indispensable.