Although many tumors of the upper respiratory tract are squamous cell carcinomas, the varied tissues of this region can give rise to a bewildering array of neoplasms. Even the recognition of squamous cell carcinoma can be quite challenging if one is confronted with a diagnostically problematic variant form. This 450-page fascicle is based on the extensive experience of three surgical pathologists who have frequently dealt with these problems, both in consultation material and in the day-to-day diagnostic challenges of a busy, nationally recognized ENT surgery service. This text reviews the full spectrum of neoplasms and neoplasmlike entities arising in the head and neck region, including the ear. (Salivary gland neoplasms have been discussed in a separate fascicle.) There are 544 high-quality 4-color and 49 halftone illustrations. Emphasis is placed on a pragmatic approach to differential diagnosis, with ample discussion of clinical features as well as ancillary diagnostic techniques, including immunohistochemistry. The fascicle begins with a review of pertinent normal anatomy and histology. The clinically and diagnostically significant variants of benign squamous neoplasia, squamous dysplasia, and squamous cell carcinoma are reviewed in detail, with appropriate emphasis on diagnostic pitfalls and their avoidance. The spectrum of non-salivary glandular neoplasms, including intestinal-type carcinomas, is presented. Entire chapters are devoted to variants of neural and neuroendocrine neoplasia as well as lymphoid neoplasms of this region. In the latter chapter, for example, the often confusing topic of T/NK cell lymphoma and the bewildering array of prior terms and concepts applied to this process are discussed in detail. Separate chapters also are devoted to vascular, fibrous, osseous, germ cell, and miscellaneous soft tissue tumors that predilect or exclusively involve this region. An additional chapter discusses diagnostically problematic tumorlike lesions, including necrotizing sialometaplasia, myospherulosis, respiratory epithelial adenomatoid hamartoma, teflon granuloma, rhinoscleroma, and similar topics. The fascicle concludes with an extensive review of benign and malignant tumors of the external, middle, and inner ear. This book should serve as an invaluable resource for pathologists confronted with these common and often troublesome specimens.