As the definitive reference for clinical chemistry, Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, 5th Edition offers the most current and authoritative guidance on selecting, performing, and evaluating results of new and established laboratory tests. Up-to-date encyclopedic coverage details everything you need to know, including: analytical criteria for the medical usefulness of laboratory procedures; new approaches for establishing reference ranges; variables that affect tests and results; the impact of modern analytical tools on lab management and costs; and applications of statistical methods. In addition to updated content throughout, this two-color edition also features a new chapter on hemostasis and the latest advances in molecular diagnostics. Section on Molecular Diagnostics and Genetics contains nine chapters that focus on emerging issues and techniques. Highly-respected author team includes three editors who are well known in the clinical chemistry world. Reference values in the appendix give you one location for comparing and evaluating test results. Companion Evolve website includes appendix material and book references linked to PubMed. NEW! Two-color design throughout highlights important features, illustrations, and content for a quick reference. NEW! Chapter on hemostasis provides you with all the information you need to accurately conduct this type of clinical testing. NEW! Six associate editors lend even more expertise and insight to the reference. NEW! Reorganized chapters ensure that only the most current information is included.

1 Introduction to principles of laboratory analyses and safety 3 2 Specimen collection and processing 41 3 Optical techniques 61 4 Electrochemistry and chemical sensors 93 5 Electrophoresis 121 6 Chromatography 141 7 Mass spectrometry 165 8 Principles of clinical enzymology 191 9 Principles of immunochemical techniques 219 10 Nanotechnology and microfabrication 245 11 Automation in the clinical laboratory 265 12 Point-of-care testing 299 13 Introduction to laboratory medicine and evidence-based laboratory medicine 323 14 Selection and analytical evaluation of methods - with statistical techniques 353 15 Clinical evaluation of methods 409 16 Establishment and use of reference values 425 17 Preanalytical variables and biological variation 449 18 Clinical laboratory informatics 475 19 Quality management 485 20 Amino acids, peptides, and proteins 533 21 Enzymes 597 22 Cytokines 645 23 Tumor markers 745 24 Kidney function tests 797 25 Carbohydrates 837 26 Lipids, lipoproteins, apolipoproteins, and other cardiovascular risk factors 903 27 Electrolytes and blood gases 983 28 Hormones 1019 29 Catecholamines and serotonin 1033 30 Vitamins and trace elements 1075 31 Hemoglobin, iron, and bilirubin 1165 32 Porphyrins and disorders of porphyrin metabolism 1209 33 Therapeutic drugs and their management 1237 34 Clinical toxicology 1287 35 Toxic metals 1371 36 Principles of molecular biology and approaches to nucleic acid isolation 1393 37 Nucleic acid techniques 1407 38 Design and operation of the molecular diagnostics laboratory 1451 39 Molecular genetics and diagnosis of hematopoietic neoplasms 1457 40 Inherited diseases 1483 41 Identity assessment 1539 42 Molecular methods in diagnosis and monitoring of infectious diseases 1555 43 Pharmacogenetics 1589 44 Cardiac function 1619 45 Kidney disease 1671 46 Physiology and disorders of water, electrolyte, and acid-base metabolism 1747 47 Liver disease 1777 48 Gastric, pancreatic, and intestinal function 1849 49 Mineral and bone metabolism 1891 50 Pituitary function 1967 51 The adrenal cortex 2003 52 The thyroid : pathophysiology and thyroid function testing 2053 53 Reproductive related disorders 2097 54 Clinical chemistry of pregnancy 2153 55 Inborn errors of amino acid, organic acid, and fatty acid metabolism 2207 56 Reference information for the clinical laboratory 2251