Following the completion of the Human Genome Project the content and organization of the third edition of Human Molecular Genetics (HMG) has been thoroughly revised. PART ONE (CHAPTERS 1-7) covers basic material on DNA structure and function, chromosomes, cells and development, pedigree analysis and the basic techniques used in the laboratory. PART TWO (CHAPTERS 8-12) discusses the various genome sequencing projects and the insights they provide into the organization, expression, variation and evolution of our genome. PART THREE (CHAPTERS 13-18) focuses on mapping, identifying and diagnosing the genetic causes of mendelian and complex diseases and cancer. PART FOUR (CHAPTERS (19-21) looks at the wider horizons of functional genomics, proteomics, bioinformatics, animal models and therapy. There are new chapters on cells and development and on functional genomics. The sections on complex diseases have been completely rewritten and reorganized, as has the chapter on Genome Projects. Other changes include a new section on molecular phylogenetics (Chapter 12) and the introduction of 'Ethics Boxes' to discuss some of the implications of the new knowledge. Virtually every page has been revised and updated to take account of the stunning developments of the past four years since the publication of the last edition of Human Molecular Genetics.

Abbreviations Preface Supplementary learning aids Before we start - Intelligent use of the Internet Ch. 1 DNA structure and gene expression 3 Ch. 2 Chromosome structure and function 33 Ch. 3 Cells and development 59 Ch. 4 Genes in pedigrees and populations 101 Ch. 5 Amplifying DNA: PCR and cell-based DNA cloning 121 Ch. 6 Nucleic acid hybridization: principles and applications 155 Ch. 7 Analyzing DNA and gene structure, variation and expression 181 Ch. 8 Genome projects and model organisms 207 Ch. 9 Organization of the human genome 239 Ch. 10 Human gene expression 275 Ch. 11 Instability of the human genome: mutation and DNA repair 315 Ch. 12 Our place in the tree of life 351 Ch. 13 Genetic mapping of Mendelian characters 397 Ch. 14 Identifying human disease genes 415 Ch. 15 Mapping and identifying genes conferring susceptibility to complex diseases 435 Ch. 16 Molecular pathology 461 Ch. 17 Cancer genetics 487 Ch. 18 Genetic testing in individuals and populations 509 Ch. 19 Beyond the genome project: functional genomics, proteomics and bioinformatics 539 Ch. 20 Genetic manipulation of cells and animals 575 Ch. 21 New approaches to treating disease 609 Glossary 631 Disease index 645 Index 647